The Russian advances appeared to bring the Kremlin closer to taking full control of Luhansk province, one of Moscow's stated war objectives, and set the stage for Lysychansk to become the main frontline city on that front.
Although the approval of the Kyiv government's application by EU leaders meeting in Brussels is just the start of what will be a years-long process, it marks a huge geopolitical shift and will anger Russia as it struggles to impose its will on Ukraine.
The Russian strikes on Kharkiv, throughout Tuesday and continuing on Wednesday morning, were the worst for weeks in the area where normal life had been returning since Ukraine pushed Russian forces back in a major counter-offensive last month.
The latest diplomatic crisis is over the Kaliningrad enclave, a port and surrounding countryside on the Baltic Sea that is home to nearly a million Russians, connected to the rest of Russia by a rail link through EU- and NATO-member Lithuania.
Moscow's separatist proxies claimed to have captured Toshkivka, a town on the mostly Ukrainian-held western bank of the Siverskyi Donets river, south of Sievierodonetsk, which has become the main battlefield city in recent weeks.
Ukraine applied to join the EU just four days after Russian troops poured across its border in February. Four days later, so did Moldova and Georgia — smaller ex-Soviet states also contending with separatist regions occupied by Russian troops.
Assange is wanted by U.S. authorities on 18 counts, including a spying charge, relating to WikiLeaks' release of vast troves of confidential U.S. military records and diplomatic cables which Washington said had put lives in danger.
On the battlefield, Ukrainian officials said their troops were still holding out against massive Russian bombardment in the eastern city of Sievierodonetsk, and described new progress in a counteroffensive in the south.
Russia had told Ukrainian forces holed up in a chemical plant in the shattered city to stop "senseless resistance and lay down arms," pressing its advantage in the battle for control of eastern Ukraine.